Front Cover in ChemSusChem

The article "Resting Escherichia coli as Chassis for Microbial Electrosynthesis: Production of Chiral Alcohols" has been selected for front cover of the ChemSusChem 8/2019 issue. 

 

Front cover of the ChemSusChem 8/2019 issue.

 
The front cover shows Escherichia coli (E. coli) as a production chassis for microbial electrochemical synthesis. This was exemplified for the conversion of acetophenone to (R)‐1‐phenylethanol with a stereoselectivity of >99 %ee by a heterologously expressed alcohol dehydrogenase of Lactobacillus brevis. The wiring of the NAD(P)+/NAD(P)H,H+ ‐ pool of E. coli to the electrode was achieved using methyl viologen, which is colorless if oxidized and deep violet in its reduced state, as mediator combined with molecular engineering using “wire” proteins from the periplasm of Shewanella oneidensis, being a model for electroactive microorganisms. This proof‐of‐concept already demonstrates a coulombic efficiency of up to 50% and a yield of approximately 40%. Thus, the work clearly lays the foundation for further microbial electrochemical synthesis of valuable pharmaceuticals and chemical building blocks. More information can be found in the Communication by Jeannine Mayr, Dr.-Ing. Jan-Handrik Grosch, Lena Hartmann, Dr. Luis Rosa, Prof. Dr.-Ing. Antje Spieß and PD. Dr. Falk Harnisch on page 1631 in Issue 8, 2019 (DOI:10.1002/cssc.201900413)